Working Groups
Data Integration Production Working Group
This group works to help integrate the analysis data generated by the focus groups and feedback to the production group to further evaluate the standards used to produce data.
Working Group Chairs
Production Working Group
This group leads the development of robust standards for evaluating techniques used to detect somatic mutations.
Working Group Chairs
Mobile Element (MEI) Analysis Focus Group
The Mobile Element (MEI) Analysis Focus Group within the Somatic Mosaicism across Human Tissues (SMaHT) Network is dedicated to identifying and characterizing somatic mobile element insertions (sMEIs) across diverse human tissues.
Working Group Chairs
SNV Analysis Focus Group
The SNV Analysis Focus Group in the SMaHT Network is dedicated to identifying and standardizing the detection of somatic single-nucleotide variants and small insertions/deletions (indels) across human tissues.
Working Group Chairs
SV Analysis Focus Group
The SV Analysis Focus Group in the SMaHT Network is dedicated to identifying and standardizing the detection of structural variants across human tissues.
Genome Assembly Analysis Focus Group
The Genome Assembly Working Group in the SMaHT Network is focused on establishing high-quality genomic assemblies to better detect and interpret somatic variation.
Working Group Chairs
Functional Focus Group
The Functional Focus Group within the SMaHT Network is dedicated to characterizing the biological impact and functional significance of somatic mutations identified throughout the network.
Working Group Chairs
Duplex Sequencing Focus Group
The Duplex Sequencing Focus Group in the SMaHT Network specializes in applying and standardizing ultra-sensitive sequencing technologies to detect rare somatic mutations with near-perfect accuracy.
Working Group Chairs
Single Cell Analysis Focus Group
The Single Cell Analysis Focus Group in the SMaHT Network is dedicated to resolving cell-type-specific mutational patterns and identifying how somatic mosaicism varies across individual cells within a tissue.
Working Group Chairs
Mitochondrial Analysis Focus Group
The Mitochondrial Analysis Focus Group within the SMaHT Network is dedicated to identifying and characterizing somatic mutations specifically within the mitochondrial genome (mtDNA).
Working Group Chairs
ELSI Working Group
The ELSI Working Group is a collaborative, interdisciplinary team designed to provide insights and feedback to the SMaHT Network about ethical, legal, and social implications of the consortium’s work and products. We help interpret and synthesize community stakeholder perspectives and also help guide both the SMaHT Network and the ELSI-specific SMaHT sub-study (IDECIDE) to ensure both projects are incorporating and honoring stakeholder perspectives and needs.
Working Group Chairs
Policy Working Group
The SMaHT Policy Working Group develops clear and consistent guidelines in support of the SMaHT Network’s objectives. These include, but are not limited to, policies pertaining to publications, privacy, data use and sharing, governance, code of conduct, and associate membership. We draft policies collaboratively within our Working Group and across the Network for feedback and approval. Once finalized, policies are published, promoting transparency and accountability. Approved policies are intermittently reviewed and updated.
Working Group Chairs
OutSMaHT Working Group
The OutSMaHT Working Group facilitates educational and training opportunities that engage the broader scientific community. We promote the SMaHT Network through social media platforms, online informational videos and tutorials, and organize workshops around SMaHT products and data releases. We also maintain the Network’s public-facing website and respond to user feedback.
Working Group Chairs
