Awardees
The following table details the awardees for the SMaHT Network.
| Component | Awardee | Institution | Title | Award Number |
|---|---|---|---|---|
| Organizational Center | Ting Wang (Contact), Heather Lawson, Lucinda Antonacci-Fulton | Washington University | WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational Center | 1U24NS132103 |
| Tissue Procurement Center | Thomas Bell | National Disease Research Interchange | Tissue Procurement Center (TPC) Supporting the Somatic Mosaicism across Human Tissues (SMaHT) Network | 1U24MH133204 |
| Data Analysis Center | Peter Park | Harvard University | Data Analysis Center for Somatic Mosaicism Across Human Tissues Network | 1UM1DA058230 |
| Genome Characterization Center | Kirstin Ardlie (Contact), John Niall, and Pradeep Natarajan | Broad Institute, Inc. | Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT) | UM1DA058235 |
| Genome Characterization Center | James Bennett (Contact), Evan Eichler, and Andrew Stergachis | University of Washington & Seattle Children’s Research Institute | Mosaicism in Human Tissues, from Telomere to Telomere to RFA-22-013: Somatic Mosaicism across Human Tissues Program: Genome Characterization Centers | UM1DA058220 |
| Genome Characterization Center | Soren Germer (Contact) and Samuel Aparicio | New York Genome Center | New York Genome Characterization Center: Somatic Mosaicism across Human Tissues | UM1DA058236 |
| Genome Characterization Center | Richard Gibbs, Rui Chen, and Harsha Doddapaneni | Baylor College of Medicine | Comprehensive Somatic Variant Characterization at the HGSC | UM1DA058229 |
| Genome Characterization Center | Ting Wang (Contact), Robert Fulton and Hui Shen | Washington University | WashU-VAI Somatic Mosaicism across Human Tissues (SMaHT) Program Genome Characterization Center | UM1DA058219 |
| Tool and Technology Development | Alexej Abyzov | Mayo Clinic Rochester | Hybrid approach for comprehensive mutation detection in a cell | UG3NS132128 |
| Tool and Technology Development | Kathleen Burns (Contact), Bradley Bernstein, and Alice Eungung Lee | Dana-Farber Cancer Institute | Single molecule detection of L1 insertions and intermediates | UG3NS132127 |
| Tool and Technology Development | Fei Chen (Contact), Jason Buenrostro, Jason Daniel, and Gad Getz | Broad Institute, Inc. | A Platform for Scalable Spatial Somatic Variant Profiling | UG3NS132135 |
| Tool and Technology Development | Sangita Choudhury (Contact), Alice Eungung Lee, and Christopher Walsh | Boston Children’s Hospital | Detection and Characterization of Somatic Mutations in Human Tissue Utilizing Duplex-Consensus Sequencing | UG3NS132144 |
| Tool and Technology Development | Gilad Evrony | New York University School of Medicine | Ultra-High Fidelity Single-Molecule Profiling of Mosaic Double- and Single-Strand DNA Mutations and Damage | UG3NS132024 |
| Tool and Technology Development | Thomas Fazzio (Contact) and Manuel Garber | University of Massachusetts Medical School Worcester | varCUT&Tag: A Method for Simultaneous Identification and Characterization of Sequence Variants in Regulatory Elements and Genes | UG3NS132136 |
| Tool and Technology Development | Fulai Jin (Contact) and Yan Li | Case Western Reserve University | Simultaneous mapping of somatic mosaicism and kb-resolution 3D genome in single cells | UG3NS132061 |
| Tool and Technology Development | Dan Landau (Contact) and Rahul Satija | Weill Medical College of Cornell University | Single-Cell Multi-omics to Link Clonal Mosaicism (CM) Genotypes with Chromatin, Epigenomic, Transcriptomic and Protein Phenotypes | UG3NS132139 |
| Tool and Technology Development | Gabor Marth (Contact) and Hunter Underhill | University of Utah | A reference-free computational algorithm for comprehensive somatic mosaic mutation detection | UG3NS132134 |
| Tool and Technology Development | Ryan Mills (Contact, Alan Boyle, and Michael McConnell | University of Michigan Ann Arbor | Molecular and Computational Tools for Identifying Somatic Mosaicism in Human Tissues | UG3NS132084 |
| Tool and Technology Development | Fritz Sedlazeck (Contact) and Tao Wu | Baylor College of Medicine | Identification of somatic/ mosaic SV and transposon activity and their crosstalk to DNA epigenetic Modifications | UG3NS132105 |
| Tool and Technology Development | Alexander Urban | Stanford University | Establishing and benchmarking advanced methods to comprehensively characterize somatic genome variation in single human cells | UG3NS132146 |
| Tool and Technology Development | Christopher Walsh (Contact) and Peter Park | Boston Children’s Hospital | Development of an Efficient High Throughput Technique for the Identification of High-Impact Non-Coding Somatic Variants Across Multiple Tissue Types | UG3NS132138 |
| Tool and Technology Development | Chenghang Zong | Baylor College of Medicine | Develop accurate high-coverage and high-throughput single-cell Duplex-seq chemistry and multi-omics platforms for simultaneous profiling of somatic mutation and the transcriptome in single human cells | UG3NS132132 |